Uncovering bifurcation behaviors of biochemical reaction systems from network topology.

ABSTRACT: The regulation of biological functions is achieved through the modulation of biochemical reaction network dynamics. The diversity of cell states and the transitions between them have been interpreted as bifurcations in these dynamics. However, due to the complexity of networks and limited knowledge of reaction kinetics, bifurcation behaviors in biological systems remain largely underexplored. To address this, we developed a mathematical method, Structural Bifurcation Analysis (SBA), which decomposes the system into substructures and determines important aspects of bifurcation behaviors-such as substructures responsible for bifurcation conditions, bifurcation-inducing parameters, and bifurcating variables-solely from network topology. We establish a direct relationship between SBA and class

SUBMITTER: Huang YJ 

PROVIDER: S-EPMC12307687 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature