LncRNA ADEPTR loss-of-function elicits sex-specific behavioral and spine deficits.

ABSTRACT: Activity-dependent neuronal changes are critical for learning and memory, but the role of long noncoding RNAs (lncRNAs) in these processes is under active investigation. In this study we investigated ADEPTR, a dendritically localized, cAMP-modulated lncRNA essential for synapse morphology. Using two mouse models-one with ADEPTR deletion (L-ADEPTR) and another lacking its protein interaction domain (S-ADEPTR)-we examined sex-specific effects on behavior and neuronal architecture. Behavioral tests showed reduced anxiety in S-ADEPTR adult male mice, with no learning or memory deficits in either model. Neuronal cultures and brain samples from various developmental stages revealed morphological impairments in both sexes. Notably, L-ADEPTR female mice had fewer thin spines in the hippocampal CA1

SUBMITTER: Chanda K 

PROVIDER: S-EPMC12307743 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature