A Large-Scale Dataset of Pre-Treatment TCR Repertoires in Colorectal Cancer Patients.

ABSTRACT: The T-cell receptor (TCR) repertoire, unique to each individual, forms a critical component of the adaptive immune system and serves as a defense mechanism against diverse pathogens. This repertoire encompasses a vast diversity of sequences, which can be profiled through high-throughput sequencing technologies. In this study, we present and provide a dataset of TCR sequencing data derived from 215 blood samples collected from newly diagnosed colorectal cancer (CRC) patients prior to any surgical or systemic treatment. Patients were classified according to the TNM staging system, enabling the inclusion of stage and risk labels specific to CRC. Dynamic changes in the TCR repertoire, such as the expansion or contraction of specific clonotypes, are known to reflect immune responses to disease

SUBMITTER: Kabeli RG 

PROVIDER: S-EPMC12307841 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature