A case of lupus nephritis with masked polyclonal IgG presenting as severe AKI, successfully treated and withdrawn from hemodialysis: a case report.

ABSTRACT: Lupus nephritis (LN) is well-known as an immune-mediated glomerulonephritis characterized by the full-house pattern of immunoglobulin (Ig) and complement deposition. The "masked IgG" is a recently recognized concept in which IgG appears negative on standard frozen sections but becomes positive on formalin-fixed paraffin-embedded (FFPE) tissue sections treated with pronase. Typically, monoclonal IgGκ deposition is observed in such cases. We report a unique case of LN in a 69-year-old male with urinary abnormalities and renal dysfunction. Kidney biopsy revealed necrotizing glomerulonephritis and crescent formation with massive subepithelial and mild subendothelial electron-dense deposits, consistent with Class III(A/C) + V LN. However, immunofluorescence using a frozen sample showed pauci-im

SUBMITTER: Takeuchi K 

PROVIDER: S-EPMC12307853 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature