Preclinical dose assessment of cyberknife with small animal intracranial irradiation using a 3D printed mouse phantom.

ABSTRACT: Dose verification in preclinical CyberKnife-based stereotactic radiosurgery (CK-SRS) of intracranial tumors is complicated by the unique characteristics of the system, including its highly conformal, non-coplanar radiation delivery and small-field irradiation. This raises concerns about the reliability of dosimetric measurements in CK-SRS radiobiological studies, emphasizing the need for standardized dosimetry protocols to improve dose accuracy and reproducibility. This study aims to evaluate a fully 3D-printed mouse phantom as a tool for preclinical intracranial CK-SRS dose verification. A 3D-printed mouse phantom was fabricated using clear resin and glass-filled polyamide (PA3200 GF) for tissue-bone-equivalent structures and modified to accommodate both EBT3 film and thermoluminescent do

SUBMITTER: Liu X 

PROVIDER: S-EPMC12307901 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature