Monobutyrin can alleviate hepatic lipid dysmetabolism and improve liver mitochondrial ultrastructure and autophagy in high-fat diet mice.

ABSTRACT: The incidence of non-alcoholic fatty liver disease has proportionally escalated alongside the global epidemic of obesity. Monobutyrin (MB), a food additive found in butter and cod liver oil, possesses lipid-regulating properties. This study aimed to explore the alleviating effect of MB on liver oxidative injury and lipid metabolism in obese mice induced by a high-fat diet (HFD). The results showed that MB administration (1 or 2 g/kg body weight (BW)) for 8 weeks significantly reduced body weight, improved hepatic lipid metabolism via activation of the peroxisome proliferator-activated receptor α (PPARα) signaling pathway, and stabilized liver mitochondrial ultrastructure to alleviate oxidative liver injury by triggering mitochondrial autophagy through regulation of microtubule-associated p

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12307903 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature