FTO-mediated MMP1 m6A modification promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the ERK pathway in congenital scoliosis.

ABSTRACT: Bone formation, metabolism, and the stability of the bone marrow microenvironment are all impacted by the imbalance in the differentiation potential of bone marrow mesenchymal stem cells (BMSCs). Despite this, it is unknown how BMSCs affect congenital scoliosis (CS). As a result, our research now focuses on explaining its associated impact and mechanism. In eukaryotic cells, N6-methyladenosine (m6A) is the most prevalent post-transcriptional alteration. The role of fat mass and obesity-related genes (FTO), an m6A demethylase, in regulating the differentiation of BMSCs is still unknown. We assessed alterations in the mRNA and protein levels of genes linked to the differentiation of BMSCs using samples taken from CS. According to our findings, According to our findings, FTO inhibits osteogen

SUBMITTER: Dai J 

PROVIDER: S-EPMC12307933 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature