Diversity of immunization strongly impacts SARS-CoV-2 antibody function surrogates.

ABSTRACT: System serology offers a comprehensive approach to evaluate the humoral immune response by evaluating multiple parameters. In the present study, based on four groups of individuals with a different history of SARS-CoV-2 immunization, we analyzed the serum of 180 individuals based on six serological methods to better decipher their immunity. Through our analysis, against different SARS-CoV-2 antigens or variants, we report the importance of system serology to better decipher population immunity. Fc-dependent parameters are key factors underlying the variability of humoral immune response triggered by different schemes of SARS-CoV-2 immunization. With an evolving exposure to new variants, the acquisition of robust cross-reactive Fc-dependent effector functions are likely to be key to control

SUBMITTER: Levast B 

PROVIDER: S-EPMC12307949 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature