Identification of a novel immature dendritic cell subset with potential pro-leukemic effects in leukemia microenvironment.

ABSTRACT: Both intrinsic and microenvironmental factors contribute to the genesis and progression of leukemia. Dendritic cells (DCs) are important members of the immunomicroenvironment. The immature DCs (imDCs) and regulatory DCs (DCregs) participate in the formation of an immunosuppressive microenvironment that play adverse role in tumor progression. However, the characteristics of DCs in leukemia microenvironment have not been well established. Here, we identified a novel CD11c⁺MHCII^lo DC population (T-DC) accumulated in the mouse splenic T-ALL microenvironment. T-DCs exhibited an immature phenotype as they were characterized by low expression of MHCII molecules and co-stimulatory molecules such as CD86, CD83 and CD40. Database analysis revealed that low level expression of D

SUBMITTER: Cui X 

PROVIDER: S-EPMC12307975 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature