Additively manufactured biodegradable porous FeMn-akermanite scaffolds for critical-size bone defects: the first <i>in vivo</i> evaluation.

ABSTRACT: Additively manufactured (AM) iron (Fe)-based scaffolds have been developed as promising biodegradable bone-substituting biomaterials. Multi-material extrusion-based 3D printing has recently yielded Fe-manganese (Mn) alloy-based scaffolds that can resolve ferromagnetism and cytotoxicity associated with Fe-based biomaterials. Herein, we, for the first time, present the findings from in vivo study on extrusion-based AM FeMn-akermanite (Ak) scaffolds for critical-size bone defect repair. The scaffolds comprised Fe, 35 wt% Mn, and 20 or 30 vol% Ak, with microporous struts and 61-63 % porosity. Both scaffolds exhibited mechanical properties within the range of trabecular bone and provided suitable sites for Ca/P deposition during in vitro biodegradation. In vitro cell cultur

SUBMITTER: Putra NE 

PROVIDER: S-EPMC12308005 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature