Integrated bioprinting of trachea-like structures based on tissue-specific bioink.

ABSTRACT: Segmental tracheal reconstruction remains clinically challenging due to insufficient blood supply and mechanical instability in current graft materials. Inspired by the natural trachea's alternating cartilage-fiber structure, we developed a 3D-bioprinted chondro-fibrous integrated trachea (CFT) using customized tissue-specific hydrogels modified with glucomannan-peptide copolymer (GM-P). This design mimics the native tissue's layered organization, combining cartilage-like rings (from iPSC-derived chondrocytes) and fibrous connective layers (from fibroblasts) through precise bioprinting. The GM-P hydrogel improved interlayer bonding and supported vascularization. Furthermore, in vivo trachea regeneration in nude mice showed satisfactory mechanical adaptability and efficient physiological re

SUBMITTER: Zheng T 

PROVIDER: S-EPMC12308022 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature