Depicting multiple sclerosis disease course using lesion parenchymal fraction: a quantified expression of the topographical model of multiple sclerosis.

ABSTRACT: The topographical model of multiple sclerosis proposes that functional reserve compensates for multiple sclerosis lesions, and that disability accumulation is the result of an insidious unmasking of deficits referable to lesion burden. To utilize topographical principles to establish an imaging metric-lesion parenchymal fraction (LPF)-defined as lesion volume divided by parenchymal volume in the same regional compartment, and to assess the relationship of LPF with disability. One hundred patients with relapsing-remitting or secondary progressive multiple sclerosis were evaluated; clinical and MRI data were longitudinally acquired from 2011-19. Lesion and parenchymal volumes in brain and cervical cord were processed using icobrain/icospine pathways, parsed into topographical compartments, a

SUBMITTER: Krieger S 

PROVIDER: S-EPMC12308131 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature