Development and validation of the VAE-NT index: a novel biomechanical parameter for distinguishing subclinical corneal abnormalities.

ABSTRACT:

Purpose

The aim of this study is to develop an index for distinguishing between very asymmetric ectasia with normal topography (VAE-NT) eyes and normal eyes, with good performance in validity, reliability, and predictive values.

Methods

In the training dataset, this single-center retrospective study involved 102 healthy eyes and 97 VAE-NT eyes. After propensity score matching (PSM), data from 53 healthy eyes and 53 VAE-NT eyes, including demographic and Corvis ST examination results, were collected. The area under the receiver operating characteristic curve (AUC), sensitivity, specificity, intraclass correlation coefficient (ICC), and positive and negative likelihood ratios were calculated for the dynamic corneal response (DCR) parameters of Corvis ST. The Technique for Orde

SUBMITTER: Yang L 

PROVIDER: S-EPMC12308140 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature