LINC01614: A Potential Therapeutic Target in Astrocytoma Progression.

ABSTRACT: Astrocytomas are aggressive brain tumours with limited treatment options, making the identification of novel therapeutic targets crucial. Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression and have been implicated in various cancers, including astrocytoma. LINC01614 is a lncRNA that has been found to be upregulated in astrocytoma, suggesting its potential role in tumour progression. In this study, we investigated the functional role of LINC01614 in astrocytoma and its interaction with miR-128, a known regulator of the RAS/Map kinase signalling pathway. Through in vitro experimental assays, we demonstrated that LINC01614 upregulation promotes astrocytoma cell proliferation and invasion, potentially through the sponging of miR-128. Furthermore, in silico analysis

SUBMITTER: Karimpour F 

PROVIDER: S-EPMC12308213 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature