CircGLIS3 Inhibits Intramuscular Adipogenesis and Alleviates Skeletal Muscle Fat Infiltration.

ABSTRACT:

Background

Intramuscular fat (IMF) is a key determinant of meat quality. Excessive IMF deposition, commonly observed in human obesity and aging, negatively affects skeletal muscle function. Circular RNAs (circRNAs) play critical regulatory roles in muscle and fat development, as well as in the progression of related diseases. However, the specific functions and underlying mechanisms of circRNAs in IMF deposition have not been extensively studied.

Methods

We screened adipogenic differentiation-related circRNAs using circRNA-seq combined with WGCNA. Functional analyses, including loss-of-function and gain-of-function experiments, were performed to determine the role of circGLIS3 in regulating adipogenesis in bovine intramuscular preadipocytes and 3T3-L1 cells. A high-fat diet-

SUBMITTER: Yu S 

PROVIDER: S-EPMC12308225 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature