Longitudinal effects of sex differences and apolipoprotein E genotype on white matter engagement among elderly.

ABSTRACT: The apolipoprotein E (APOE) ɛ4 allele is the primary genetic risk factor that influences lipid metabolism and contributes to distinctive Alzheimer's disease pathologies, including increased hippocampal atrophy and accelerated cognitive decline. Synaptic dysfunction can occur in APOE4 carriers even before the appearance of any clinical symptoms. Recent evidence has suggested that this genetic risk factor impacts males and females differently. The sex-specific vulnerability for females to cognitive decline, particularly memory, intensifies post-menopause and emphasizes the need for further investigation. White matter abnormalities, APOE4 allele and disruptions in default mode network connectivity serve as early indicators that are crucial for better understanding Alzheim

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12308282 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature