Tetrahedron DNA Nanostructures as microRNA Inhibitors to Alleviate Acute Pancreatitis.

ABSTRACT: Acute pancreatitis (AP) is an inflammatory pancreatic disorder characterized by tissue damage and necrosis. It not only affects the pancreas but also triggers systemic inflammatory responses, leading to multiorgan failure and potentially death. In recent years, microRNA (miRNA) sponges have demonstrated promise to enhance AP treatment outcomes by inhibiting specific miRNAs. However, the clinical implementation of these inhibitors is often compromised by their structural instability. In this study, we developed a tetrahedron DNA nanostructure (TDN) with a single-stranded DNA segment designed to capture miR-21-3p, a potential therapeutic target for AP, forming a robust miRNA inhibitor. The TDNs exhibited enhanced stability compared to conventional single-stranded miRNA inhibitors, allowing f

SUBMITTER: Li Y 

PROVIDER: S-EPMC12308373 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature