Expanding Meroterpenoid Chemical Space Via Intermolecular Trapping of Cationic Cyclization Intermediates.

ABSTRACT: Meroterpenoids are a subclass of terpenes that consist of a nonterpene part, that is, in many cases, an aryl residue, linked to a terpene component. Their biosynthesis involves the attachment of the aryl group to the tail end of the acyclic terpene part, followed by terpene cyclization. Here we explore an alternative method for accessing meroterpenoids. The terpene cyclization is performed in the presence of arenes that trap key cationic intermediates in an intermolecular fashion. Our study demonstrates the feasibility of this approach that, to our knowledge, has not been reported before. It enables direct access to the novel meroterpenoid chemical space.

SUBMITTER: Cornu I 

PROVIDER: S-EPMC12308376 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature