CircEFR3A promotes breast cancer progression by sponging miR-590-3p to upregulate androgen receptor expression.

ABSTRACT: Circular (circ)RNA, a type of non-coding RNA, serves a critical role in several diseases, including cancer. The present study aimed to elucidate the involvement of hsa_circ_0006522 (circEFR3A) in the advancement of breast cancer (BC) and uncover the molecular mechanisms behind its function. Fluorescence in situ hybridization (FISH) was performed on a tissue microarray to assess the expression and intracellular localization of circEFR3A. Kaplan-Meier analysis and Cox proportional hazards model were utilized to evaluate the potential prognostic significance of circEFR3A in relation to the overall survival of patients with BC. The biological function was assessed through gain- and loss-of-function experiments. In addition, dual luciferase reporter assays, RNA immunoprecipitation, FISH

SUBMITTER: Mi Y 

PROVIDER: S-EPMC12308457 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature