Highly genetically diverse variants of hepatitis C virus still predominate in Cameroon but with low frequency of mutations associated to resistance of NS5B polymerase-targeted antivirals.

ABSTRACT:

Background

Hepatitis C is of low endemicity (<2%) in the general population in Cameroon, with genotypes (GTs) 1, 2 and 4 reported frequently identified. In 2016, direct-acting antiviral agents (DAAs) were included in the Treatment Guidelines for hepatitis C in Cameroon. The aim of this study was to investigate hepatitis C virus (HCV) variability and frequency of NS5B naturally occurring polymorphisms and transmitted resistance-associated mutations or substitutions (RAMs or RASs) in DAAs-naïve patients.

Methods

From 240 HCV-infected, DAA-naïve individuals, the NS5B region of 92 samples were sequenced, genotyped by phylogeny using MEGA 11.0.13 software and analysed for polymorphisms conferring resistance to polymerase inhibitors using bioinformatics tools (Geno2Pheno HCV 0.92

SUBMITTER: Levoa Eteme F 

PROVIDER: S-EPMC12308484 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature