Mass Spectrometry Imaging Reveals That Gold Nanomaterial Surface Chemistry Affects Transport and Excretion in Mice over Time.

ABSTRACT: Nanoparticles (NPs) are versatile tools in various applications, particularly in the biomedical fields. To understand their behavior within biological systems, it is crucial to measure their distributions in vivo, especially as they interact with the immune system and excretory organs, to ensure their efficacy, safety, and clearance. Here, we demonstrate the unique capabilities of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging for revealing the temporal redistribution of gold NPs (AuNPs) in key excretory organs. The quantitative and suborgan specific information available in LA-ICP-MS measurements indicate that positive AuNPs are more rapidly excreted through the hepatobiliary system of the liver than AuNPs having other surface charges. Using multiel

SUBMITTER: Doungchawee J 

PROVIDER: S-EPMC12308589 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature