Obesity increases the risk of hepatic fibrosis in young adults with type 2 diabetes mellitus: the need to screen.

ABSTRACT:

Objective

The objective of this study was to determine the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in young compared with older adults.

Methods

Individuals (n = 1420) with (63%) and without type 2 diabetes mellitus (T2D; 37%) who attended internal medicine clinics and did not have a known history of MASLD underwent laboratory evaluation and transient elastography to assess for hepatic steatosis and fibrosis. Magnetic resonance elastography and liver biopsy were recommended when indicated.

Results

A total of 243 participants were ages <45 years, and 1177 were ages ≥45 years. Obesity, T2D, and metabolic syndrome were highly prevalent in young adults. Frequencies of steatosis and fibrosis were high in young adults (50.2% and 7.5% vs

SUBMITTER: Sharma A 

PROVIDER: S-EPMC12308620 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature