Associations of Infertility With Depressive Symptom Change Across Specific Life Stages (Pregnancy, Postpartum, and Midlife) Among Parous Women.

ABSTRACT:

Background

Limited longitudinal data exist on the associations of infertility with depressive symptoms across the lifecourse.

Objectives

To investigate how depressive symptoms change across specific life stages (pregnancy, postpartum, and midlife), with a focus on the differences between women with and without a history of infertility before index pregnancy.

Methods

Women enrolled in Project Viva (1999-2002) during early pregnancy (mean [SD] age 32.5 [4.7] years) completed the Edinburgh Postnatal Depression Scale (EPDS) in mid-pregnancy (median 27.9 weeks gestation) and at 6 months postpartum, and completed the Patient Health Questionnaire (PHQ-9) in midlife (2017-2021, 50.9 [5.1] years). We converted EPDS and PHQ-9 scores to externally standardised T-scores (mean = 5

SUBMITTER: Perez Capotosto M 

PROVIDER: S-EPMC12308624 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature