Maternal Age Differences in Interpregnancy Interval and Preterm Birth Associations Accounting for Multiple Epidemiologic Biases.

ABSTRACT:

Background

People who recently gave birth are strongly advised to wait 6 months before attempting pregnancy. Interpregnancy intervals (IPI) of ≥ 18 months are considered optimal. Current guidance is not tailored based on maternal characteristics (e.g., age).

Objectives

We evaluated whether maternal age modifies IPI-preterm birth (PTB) associations.

Methods

From a US retrospective cohort of multiparae (1997-2011), we categorised IPI: < 6, 6-11, 12-17, 18-23 (reference), 24-59 or ≥ 60 months. PTB occurred before 37 0/7 weeks' gestation. We estimated risk ratios (RR) between IPI and PTB using modified Poisson regression, adjusted for potential confounders and stratified by age at prior delivery: < 25 (n = 2484), 25-29 (n = 1626) or ≥ 30 (n = 1209) years. We conducted qua

SUBMITTER: Petersen JM 

PROVIDER: S-EPMC12308627 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature