Placental Malaria Induces Oxidative Stress in Human Syncytiotrophoblast.

ABSTRACT:

Background

Placental malaria is characterized by the accumulation of Plasmodium falciparum-infected erythrocytes and maternal inflammation in the intervillous spaces of the placenta. These features are associated with placental damage and fetal compromise. However, understanding of the mechanisms that lead to poor pregnancy outcome and interventions targeting excessive host responses to placental malaria are still lacking. The syncytiotrophoblast, a cell of fetal origin, is known to be responsive to malaria-infected erythrocytes as well as the malaria toxin, hemozoin, but its susceptibility to oxidative stress and how this might contribute to placental damage and dysfunction has not yet been directly investigated.

Methods

The characteristics and key drivers of the syncytiotr

SUBMITTER: Sarr D 

PROVIDER: S-EPMC12308658 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature