Estimating the Serotype-Specific Association Between the Concentration of Vaccine-Induced Serum Antibodies and Protection Against Pneumococcal Colonization.

ABSTRACT:

Background

Pneumococcal conjugate vaccines (PCVs) offer indirect protection by reducing pneumococcal colonization in the vaccinated children and thus transmission. As higher-valency PCVs may trigger a weaker immune response, it is important to understand how differences in immunogenicity between PCVs translate to effectiveness against colonization.

Methods

We estimated the serotype-specific relationship between the concentration of vaccine-induced serum immunoglobulin G (IgG) and protection against colonization using a hierarchical Bayesian model with the longitudinal data from a randomized controlled trial. We then combined these estimates with the summary-level immunogenicity data (geometric mean concentrations and 95% confidence intervals) from head-to-head clinical trial

SUBMITTER: Wong A 

PROVIDER: S-EPMC12308679 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature