Circulating Hepatitis B Virus (HBV) RNA and Conventional Markers in Treatment-Naive Persons With HBV in Senegal.

ABSTRACT:

Background

Hepatitis B virus (HBV) infection affects approximately 10% of the general population in West Africa. Circulating HBV RNA may help improve the characterization of HBV disease and prognosis. We aimed to evaluate the associations between HBV RNA and conventional biomarkers of HBV replication in the Senegalese Hepatitis B Cohort Study (SEN-B).

Methods

We included all treatment-naive, human immunodeficiency virus-negative participants of SEN-B with chronic HBV infection confirmed by a quantitative hepatitis B surface antigen (HBsAg) >0.05 IU/mL. We quantified HBV RNA, HBV DNA, and HBsAg levels and evaluated associations between those markers stratified by HBV infection phase, alanine aminotransferase level, and liver fibrosis stage.

Results

Of 719 participants,

SUBMITTER: Begre L 

PROVIDER: S-EPMC12308681 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature