Aryl halide cross-coupling via formate-mediated transfer hydrogenation.

ABSTRACT: Transfer hydrogenation is widely practised across all segments of chemical industry, yet its application to aryl halide reductive cross-coupling is undeveloped because of competing hydrogenolysis. Here, exploiting the distinct reactivity of Pd^I species, an efficient catalytic system for the reductive cross-coupling of activated aryl bromides with aryl iodides via formate-mediated hydrogen transfer is described. These processes display orthogonality with respect to Suzuki and Buchwald-Hartwig couplings, as pinacol boronates and anilines are tolerated and, owing to the intervention of chelated intermediates, are effective for challenging 2-pyridyl systems. Experimental and computational studies corroborate a unique catalytic cycle for reductive cross-coupling where the Pd^I

SUBMITTER: Cho Y 

PROVIDER: S-EPMC12308758 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature