Organometallic Half-Sandwich Complexes of 1,10-Phenanthroline Derivatives with Improved Solubility, Albumin-Binding, and Nanoformulation Potential Targeting Drug Resistance in Cancer.

ABSTRACT: The development of Rh(III)(η⁵-C₅Me₅) and Ru(II)(η⁶-p-cymene) complexes of 4,7-dichloro-1,10-phenanthroline (DCP) and bathophenanthroline (BP) aims to increase aqueous solubility and potential bioavailability of the lipophilic ligands while also enabling selective activity against multidrug-resistant (MDR) cancer cells. Complexes [M(η⁶-arene/η⁵-arenyl)(DCP/BP)Cl]Cl were prepared and characterized by means of nuclear magnetic resonance, infrared, electrospray ionization mass spectrometry, and single crystal X-ray diffraction for [Rh(III)(η⁵-C₅Me₅)(DCP)Cl]PF₆ and [Ru(II)(η⁶-p-cymene)(BP)Cl]PF₆. The complexes are highly stable in a wide pH range with

SUBMITTER: Varkonyi EF 

PROVIDER: S-EPMC12308784 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature