Conformational Dynamics and Binding Interactions of SARS-CoV-2 Spike Protein Variants: Omicron, XBB.1.9.2, and EG.5.

ABSTRACT: The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has continuously evolved, generating numerous variants with varying degrees of infectivity and transmissibility. The EG.5 subvariant of SARS-CoV-2 emerged globally in mid-2023 as part of the ongoing evolution of the Omicron lineage. Derived from the recombinant XBB.1.9 sublineage, EG.5 has attracted attention due to its enhanced immune escape and sustained transmissibility. As a member of the FLip lineage, EG.5 harbors the convergent F456L mutation in the spike receptor-binding domain (RBD), a key residue for neutralizing antibody recognition. Understanding the molecular mechanisms underlying these variations is crucial for developing effective antiviral strategies. In this study, we employed accelerated molecular dynamics simula

SUBMITTER: da Costa CHS 

PROVIDER: S-EPMC12308811 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature