Speciation and structural transformation of a V^V-malate complex in the absence and in the presence of a protein: from a dinuclear species to decavanadate.

ABSTRACT: A strategy for the development of new vanadium-based drugs is the preparation of complexes that target proteins and bear molecules involved in the cellular metabolism as ligands, like α-hydroxycarboxylic acids. Based on these premises, this study explores the solution behaviour of the dioxidovanadium(V) complex of malic acid, Cs₂[V^V ₂O₄(mal)₂]·2H₂O, and its interaction with the model protein lysozyme (HEWL) at room and at physiological temperature using ⁵¹V nuclear magnetic resonance (NMR), electrospray ionisation-mass spectrometry (ESI-MS) and X-ray crystallography. The results show the coexistence in aqueous solution of various molecular species containing two or ten V^V centres. In solution these spec

SUBMITTER: Paolillo M 

PROVIDER: S-EPMC12308817 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature