The prognostic impact of net ultrafiltration intensity in critically ill patients receiving continuous renal replacement therapy: a multivariable and propensity-matched analysis.

ABSTRACT:

Objectives

Net ultrafiltration (UF^net) is widely used for fluid management during continuous renal replacement therapy (CRRT) for critically ill patients over extended periods. Despite widespread use, the relationship between UF^net intensity and clinical outcomes, particularly mortality, remains controversial.

Methods

This retrospective observational study examined critically ill patients undergoing CRRT for more than 72 h from January 2021 to September 2023. Patients were stratified by their UF^net intensity during the initial 72 h of CRRT into low (<1.01 mL/kg/h), moderate (1.01-1.75 mL/kg/h), and high (>1.75 mL/kg/h) groups. The primary outcome was 28-day mortality. Kaplan-Meier's survival curves with log-rank tests, Cox proportional hazard

SUBMITTER: Jin L 

PROVIDER: S-EPMC12308870 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature