Esketamine for Preventing Catheter-Related Bladder Discomfort After Ureteroscopic Lithotripsy: A Randomized Controlled Trial.

ABSTRACT:

Background

Catheter-related bladder discomfort (CRBD) is associated with anxiety, pain, and an increased risk of perioperative complications. Esketamine, which exhibits analgesic and anticholinergic properties, may offer therapeutic benefits in this context. This study aims to evaluate the effects of varying sub-anesthetic doses of esketamine on the incidence and severity of CRBD following ureteroscopic lithotripsy.

Methods

A total of 168 patients were randomly assigned to three groups: Esk15 (0.15 mg/kg esketamine), Esk25 (0.25 mg/kg esketamine), and a placebo group (2 mL saline). The primary outcome was the incidence of moderate-to-severe CRBD at 0 h postoperatively. Secondary outcomes included the incidence and severity of CRBD at 0, 1, 2, and 6 h postoperatively, esketam

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12308904 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature