Identification of differentially expressed immune-related genes in patients with systemic lupus erythematosus and the development of a hub gene-based diagnostic model.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease that affects body tissues, but it can be managed with medication. Although therapeutic strategies for SLE have advanced, the underlying molecular mechanisms driving disease pathogenesis remain incompletely understood.

Methods

This study analyzed gene expression data from three GEO microarray datasets to explore immunity-related differentially expressed genes (DEGs) in SLE. Using WGCNA, we identified gene modules and integrated them with immune-related DEGs to find candidate hub genes, which were validated using RT-qPCR. We constructed a PPI network and performed gene enrichment analysis to identify nine hub genes through ROC curve analysis. We confirmed the link between these hub genes and immun

SUBMITTER: Fang Q 

PROVIDER: S-EPMC12308984 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature