Co-resistance and plasmid-mediated co-dissemination of florfenicol and azithromycin resistance in non-O157 Shiga toxin-producing Escherichia coli from cattle in Xinjiang, China.

ABSTRACT:

Background

Florfenicol is a critical antibiotic used in cattle to manage respiratory infections, while azithromycin is recommended for treating early-stage Shiga toxin-producing Escherichia coli (STEC) infections. This study focused on examining the co-resistance and mechanisms of co-dissemination of resistance to florfenicol and azithromycin in 367 non-O157 STEC strains isolated from cattle in Xinjiang between 2015 and 2023.

Results

Among these isolates, 16.3% showed resistance, with drug resistance rates ranging from 5.4 to 10.6% for tetracycline, ampicillin, cefotaxime, streptomycin, sulfamethoxazole, florfenicol, aztreonam, azithromycin, gentamicin, ceftazidime, and piperacillin. Resistance to cefepime, ampicillin-sulbactam, amikacin, amoxicillin-clavulanic acid, levoflo

SUBMITTER: Wang L 

PROVIDER: S-EPMC12309106 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature