Concurrent nonalcoholic fatty liver disease may decrease liver fibrosis severity in patients with primary biliary cholangitis.

ABSTRACT:

Background

The purpose of this study was to evaluate how nonalcoholic fatty liver disease (NAFLD) impacts the progression and prognosis of primary biliary cholangitis (PBC).

Methods

This retrospective study enrolled patients diagnosed with PBC. NAFLD patients were identified according to the 2023 American Association for the Study of Liver Diseases guidelines. The primary outcome measured the percentage of patients achieving a complete biochemical response as defined by the Paris criteria, while secondary outcomes included non-invasive fibrosis scoring systems and a transplantation-free survival risk model. Statistical analyses employed independent samples Student's t-test or Mann-Whitney U test for continuous variables and Pearson's chi-square or Fisher's exact test for cat

SUBMITTER: Ren W 

PROVIDER: S-EPMC12309127 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature