Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask.

ABSTRACT:

Background

Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway. While several known elements contribute to maintaining cellular homeostasis by modulating Notch signaling, many unidentified components likely play significant roles in its regulation, necessitating further exploration.

Methods

To identify novel regulators of Notch-intracellular domain (Notch-ICD), we carried out a yeast two-hybrid screen and identified Multiple Ankyrin repeat single KH domain containing protein (Mask) as an interacting partner of Notch-ICD. Physical interaction between these two proteins was further validated by co-i

SUBMITTER: Sarkar B 

PROVIDER: S-EPMC12309132 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature