Integrated plasma and red blood cell membrane lipidomics analysis unveils novel biomarker panel for Alzheimer's disease.

ABSTRACT:

Background

Discovering new biomarkers for Alzheimer's disease (AD) are significant for early diagnosis and monitoring disease's progression. Blood-based lipid biomarkers, particularly from red cell membranes, offer a non-invasive alternative, providing insights into AD progression and potential therapeutic targets.

Methods

This study innovatively incorporates red cell membrane (RCM) lipids, which reflect chronic physiological alterations and are linked to AD pathogenesis. A comprehensive lipid detection platform was employed to analyze lipid profiles from 156 individuals, including normal subjects, those with amnestic mild cognitive impairment, and AD patients. Differential lipids were identified and validated to be AD-associated by correlation analysis and big data analysis

SUBMITTER: He D 

PROVIDER: S-EPMC12309142 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature