Genetic susceptibility of human leukocyte antigen alleles in chronic inflammatory demyelinating polyneuropathy in Korean patients : Short title: HLA alleles and CIDP in Korea.

ABSTRACT:

Background

The pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP) is still not fully understood, but HLA polymorphisms have been implicated in immunogenesis. In the present study, we aimed to identify HLA alleles susceptible to CIDP in the Korean population.

Methods

We retrospectively analyzed 27 Korean patients with CIDP diagnosed at Samsung Medical Center between 2016 and 2022. Clinical features and nodal/paranodal antibodies were assessed. HLA-DRB1, DPB1, and DQB1 genotyping was performed using the Luminex-based oligonucleotide probe method. Autoimmune nodopathy (AN) was defined by the presence of anti-NF155, anti-contactin-1, or anti-CASPR1 antibodies confirmed by cell-based assay. Allele frequencies were compared with those from 173 healthy Korean

SUBMITTER: Kwon S 

PROVIDER: S-EPMC12309156 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature