Differences in gait apraxia due to reduced regional cerebral blood flow in the supplementary motor area in corticobasal syndrome: a report of two cases.

ABSTRACT:

Background

Gait apraxia, characterized by difficulties initiating and coordinating walking despite preserved conceptual movement abilities, is a distinct entity from lower limb apraxia. Although gait apraxia has been associated with dysfunction of the frontal lobe, particularly the supplementary motor area (SMA), the specific associated somatotopic organization phenotype remains poorly understood. Corticobasal syndrome (CBS), a clinical phenotype of corticobasal degeneration, commonly presents with upper limb apraxia, while lower limb or gait apraxia has rarely been reported. Herein, we describe two rare cases of CBS presenting with gait apraxia shown to be caused by SMA dysfunction, based on regional cerebral blood flow (rCBF) reduction on single-photon emission computed tomograph

SUBMITTER: Igari K 

PROVIDER: S-EPMC12309158 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature