Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma.

ABSTRACT:

Introduction

Retrotransposons (REs) constitute nearly half of the genome and include long terminal repeat (LTR) elements, Long INterspersed Elements (LINE), and Short INterspersed Elements (SINE). REs are typically silenced in somatic tissues via DNA methylation but can be reactivated through DNA hypomethylation, potentially impacting gene regulation. Here, we investigate genome-scale profiles of RE methylation in high-grade serous ovarian carcinoma (HGSOC) and associations with survival among Black women.

Methods

Methylation levels of LTR, LINE-1, and Alu (type of SINE) in 200 HGSOC tumors were predicted using a random forest approach and clustered using multiple consensus algorithms. Associations between RE methylation clusters and survival were evaluated using Cox proport

SUBMITTER: Colin-Leitzinger C 

PROVIDER: S-EPMC12309203 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature