In Vivo Wound Healing and Immune Response Studies of Chitosan Cryogels With Invertebrate Model Organism Galleria mellonella.

ABSTRACT: In the present study, it was aimed to prepare single and double network chitosan (Ch) cryogels cross-linked with glutaraldehyde (G), which can be recommended for use as model wound dressings and hemostatic agents, and to reveal in vivo studies with Galleria mellonella. An in vivo study about Ch cryogels with these larvae was not declared in the literature, so our study is the first of its kind. G. mellonella was used to determine the effects of cryogels on immunity, oxidative stress, and wound healing. Cinnamic acid (CA) was loaded onto the cryogels, and the percent cumulative release data of CA were found to be in the range of 69%-80%. The results show that loading of CA onto [Ch-3]_cry cryogels considerably improved immune responses; the [Ch-3]_cry-CA group was the mo

SUBMITTER: Ekici S 

PROVIDER: S-EPMC12309346 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature