Involvement of a stress-responsive orbito-striatal projection in impulsive action in male rats.

ABSTRACT:

Background

Motor impulsivity is a symptom shared by several psychiatric disorders. Stress exacerbates impulsivity, but the neurocircuits involved are unknown. We have shown that the orbitofrontal cortex (OFC) is activated during a rodent motor impulsivity task and that chronic unpredictable stress (CUS) increases premature responding. In this study, we examine the role of the OFC projection to dorsal medial striatum (DMS) in motor control, and test whether this pathway mediates the effects of stress on impulsive action.

Methods

Motor impulsivity was measured with the 1-choice serial reaction time test (1-CSRTT). To determine if OFC-DMS projections are involved in controlling impulsivity, we used pathway-specific Designer Receptors Exclusively Activated by Designer Drugs (DRE

SUBMITTER: Girotti M 

PROVIDER: S-EPMC12309362 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature