Lactam-fused tropolones: a new tunable, environmentally sensitive fluorophore class.

ABSTRACT: Fluorescent small-molecules capable of altering their profiles in response to environmental changes are exceptionally valuable tool compounds throughout the scientific community. The following manuscriipt describes a new class of fluorescent small molecules based on lactam-fused tropolones that are responsive to a dynamic range of environmental changes. These molecules can be easily obtained through a rapid annulation procedure between appropriately functionalized tropolones and primary amines, which is often complete within minutes at room temperature. Molecules generated through this approach have been identified with fluoresence emission across the visible light spectra, and can be tuned based on either the tropolone or amine component. They are also highly responsive to changes in solv

SUBMITTER: Schiavone DV 

PROVIDER: S-EPMC12309396 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature