Positive social relations, loneliness, and immune system gene regulation.

ABSTRACT: Perceived isolation (i.e., loneliness) has been linked to an immune response gene profile known as the conserved transcriptional response to adversity (CTRA), but little is known about how positive social relations might affect human genome function. We analyzed two studies of Korean adults to determine whether the positive qualities of an individual's general social relations with others (warmth, satisfaction, and trust; as measured by the Positive Relations with Others [PRWO] subscale of the The Ryff Scales of Psychological Well-being) might be inversely associated with CTRA gene expression. In Study 1 (53 participants, mean age = 72 years, 47% female), PRWO were significantly associated with reduced CTRA profiles, even after controlling for loneliness. Similarly, in Study 2 (152 partici

SUBMITTER: Lee SH 

PROVIDER: S-EPMC12309429 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature