Characteristics and significance of γδ T cells in colorectal cancer.

ABSTRACT: Gamma-delta T cells are a subset of T cells that have features of both innate and adaptive immunity. Their role in cancer remains controversial, since both anti- and protumor functions have been reported. We aimed to shed light on the distinct characteristics of γδ T cells in colorectal cancer (CRC). In two independent cohorts, including 1 687 CRC patients, we identified γδ and αβ T cells with multiplex immunohistochemistry to evaluate their prognostic significance. To further analyze the characteristics of γδ T cells, we utilized single-cell RNA sequencing data of 62 CRC patients. High γδ T cell densities were associated with prolonged survival in both cohorts, and this association was independent of other tumor and patient characteristics in Cohort 1, where the multivariable HR for high

SUBMITTER: Karjalainen H 

PROVIDER: S-EPMC12309541 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature