New Immunohistochemical Findings on Amelogenin and Dentin Sialophosphoprotein in Genetic Tooth Diseases.

ABSTRACT:

Objective

Diseases that affect teeth can change their structure and the distribution and expression of amelogenin (AMELX) and dentin-sialophosphoprotein (DSPP). This study aimed to conduct a histopathological, ultrastructural, and immunohistochemical comparison of AMELX and DSPP in teeth from patients with amelogenesis imperfecta (AI), dentinogenesis imperfecta (DI), osteogenesis imperfecta (OI), regional odontodysplasia (ROD), and control teeth. Additionally, a model of the structure of the affected primary teeth is proposed.

Design

This case series study examined 27 affected teeth with various diseases and 14 control teeth. Some teeth were analysed using light microscopy, polarised light, and scanning electron microscopy, while others underwent decalcification for histolog

SUBMITTER: Camacho-Escalera C 

PROVIDER: S-EPMC12309598 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature