Real-world effectiveness of immunoglobulin replacement for hypogammaglobulinemia and infections in multiple myeloma.

ABSTRACT:

Abstract

This study assessed the real-world effectiveness of immunoglobulin replacement therapy (IgRT) for treatment of hypogammaglobulinemia and infections in patients with multiple myeloma (MM). A retrospective study was conducted on adult patients diagnosed with MM on or after 1 January 2010 using the Mass General Brigham Research Patient Data Registry. Infections were compared before and after IgRT initiation. Generalized estimating equation logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). In patients with accessible serum protein electrophoresis (SPEP) test results, a Natural Language Processing program supported the extraction of immunoglobulin G (IgG) data. The IgG assessments and incidence of hypogammaglobulinemia (defi

SUBMITTER: O'Donnell E 

PROVIDER: S-EPMC12309603 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature