A molecular basis underpinning TRBV28⁺ T-cell receptor recognition of MR1-antigen.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells express a TRAV1-2⁺ T-cell receptor (TCR) that recognizes microbial vitamin B2 derivatives presented by the major histocompatibility complex class I-related molecule (MR1). Most MAIT TCRs incorporate a biased TCR-β repertoire, predominantly TRBV20-1 and TRBV6, but some utilize other trbv genes, including TRBV28. A second conserved, albeit less frequent TRAV36⁺ TRBV28⁺ T-cell population exhibits MAIT-like phenotypic features but use a markedly distinct mode of MR1-antigen (Ag) recognition compared with MAIT TCR-MR1 binding. Nevertheless, our understanding of how differing TCR gene usage results in altered MR1 binding modes remains incomplete. Here, binding studies demonstrated differential affinities and Ag specific

SUBMITTER: Awad W 

PROVIDER: S-EPMC12309606 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature