Biomimetic targeted self-adaptive nanodrug for inflammation optimization and AT2 cell modulation in precise ARDS therapy.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is a lethal respiratory condition, while effective pharmacological treatments remain elusive. We identified the decreased mechanical capacity and impaired proliferation of alveolar type 2 (AT2) epithelial cells in the inflammatory environment as the primary contributors to respiratory failure of ARDS. A biomimetic, self-adaptive, 7,8-dihydroxyflavone-loaded hollow mesoporous cerium oxide coated with a platelet membrane (HCeO_x-D@PM) was developed for precise ARDS therapy. HCeO_x-D@PM comprises a platelet membrane (PM) shell for targeted delivery to injured lungs and an HCeO_x core, which enables high drug loading, efficient reactive oxygen species (ROS) scavenging, and penetration of the alveolar-

SUBMITTER: Chen C 

PROVIDER: S-EPMC12309668 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature